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Research Paper | Pharmaceutical Science | India | Volume 8 Issue 9, September 2019

Desloratadine Microemulsion Based Solid Lipid Nanoparticles

Varsha Dute | Vijay Mahajan | Amol Deshmukh

Abstract: In this study, novel and main objective of this research work was to formulate and evaluate the Microemulsion Based Solid lipid Nanoparticles. Desloratadine o/w microemulsion based SLN was prepared to enhanced solubility. Desloratadine saturated solubility determined in different oils, Surfactants and co-surfactants. Sunflower oil, as oily phase and Tween 80 as surfactants and co-surfactants Propylene glycol used for pseudo ternary phase diagrams was constructed to identify the microemulsion regions. Evaluation Drug content, Drug release, Emulsification time, Visual inspection. pH, Particle size. Solid SLN – DSC, XRD, SEM, FT-IR, Refractive index, Drug Release.

Keywords: Solid lipid Nanoparticles, Microemulsion, SEM, XRD, Spray drying

Edition: Volume 8 Issue 9, September 2019,

Pages: 1274 - 1287