Desloratadine Microemulsion Based Solid Lipid Nanoparticles

Varsha Dute, Vijay Mahajan, Amol Deshmukh

Abstract: In this study, novel and main objective of this research work was to formulate and evaluate the Microemulsion Based Solid lipid Nanoparticles. Desloratadine o/w microemulsion based SLN was prepared to enhanced solubility. Desloratadine saturated solubility determined in different oils, Surfactants and co-surfactants. Sunflower oil, as oily phase and Tween 80 as surfactants and co-surfactants Propylene glycol used for pseudo ternary phase diagrams was constructed to identify the microemulsion regions. Evaluation Drug content, Drug release, Emulsification time, Visual inspection. pH, Particle size. Solid SLN – DSC, XRD, SEM, FT-IR, Refractive index, Drug Release.

Keywords: Solid lipid Nanoparticles, Microemulsion, SEM, XRD, Spray drying

How to Cite?: Varsha Dute, Vijay Mahajan, Amol Deshmukh, "Desloratadine Microemulsion Based Solid Lipid Nanoparticles", Volume 8 Issue 9, September 2019, International Journal of Science and Research (IJSR), Pages: 1274-1287, https://www.ijsr.net/getabstract.php?paperid=ART2020852, DOI: https://dx.doi.org/10.21275/ART2020852