Effect of Glyphosate (GLP) on Organ Weights in Wistar Rats and its Amelioration with Ascorbic Acid

M. Lakshmi Namratha, M. Lakshman, M. Jeevanalatha, B. Anil Kumar

Abstract: The aim of this study was to analyze the effect of glyphosate of organ weights and the protective role of Ascorbic Acid (AA) in male albino Wistar rats. Forty eight (48) rats were randomized into four groups consisting of twelve (12) animals in each Group 1 served as control, group 2 received glyphosate at a dose of 500 mgkg b. wt, group 3 received Vitamin C at a dose of 250 mgkg b. wt and group 4 received glyphosate (500 mgkg b. wt) and Vitamin C (250 mgkg b. wt). The treatment regimens were administered by oral gavage once daily for three weeks. Results showed a significant reduction in the absolute weights of testes, liver and kidneys in glyphosate treated groups. However, administration of Vitamin C caused a mild ameliorative effect on the parameters investigated.

Keywords: glyphosate, organ weights, Vitamin C and albino Wistar