International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 119 | Views: 260 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Pharmaceutical Science | India | Volume 8 Issue 9, September 2019 | Popularity: 6.9 / 10


     

A Study on Formulation and Evaluation of Oral Dispersible Tablets - Propranolol HCL

D. Radhika


Abstract: The main objective of the present work is to develop oral disintegrating of tablets of Propranolol hydrochloride. This study was aimed, which can disintegrate or dissolve rapidly once placed in the oral cavity. Propranolol hydrochloride is a Antihypertensive drug, which undergoes extensive hepatic degradation (76 %), which have poor oral bioavailability for overcoming this problem oral disintegrating of tablets of Propranolol hydrochloride can be formulated which avoids extensive first pass metabolism and improvement in dissolution efficacy, disintegration time which results in improvement in bioavailability. The ODTs are prepared by direct compression technique. All the prepared formulations were subjected to various evaluation parameters like hardness, thickness, friability, weight variation, wetting time, water absorption ratio, in-vitro dispersion time, in-vitro disintegration, and in-vitro dissolution. The optimised formulation of F5 oral disintegrating tablets containing crosspovidone showed hardness of 4.2kg/cm2, thickness of 2.61mm, friability of 0.28 %, wetting time 45sec, water absorption ratio of 69 %, disintegration time of 22 sec, content uniformity of 20.28mg and in-vitro drug release of 97.4 % better than other formulations containing sodium starch glycolate and cross carmellose sodium. The advantage of this formulation is such that in case of hypertension attack patient can take the drug without the usage of water.


Keywords: Propranolol HCl, Super disintegrants, Oral disintegrating tablets, Disintegration time, Direct compression


Edition: Volume 8 Issue 9, September 2019


Pages: 1527 - 1533



Make Sure to Disable the Pop-Up Blocker of Web Browser


Text copied to Clipboard!
D. Radhika, "A Study on Formulation and Evaluation of Oral Dispersible Tablets - Propranolol HCL", International Journal of Science and Research (IJSR), Volume 8 Issue 9, September 2019, pp. 1527-1533, https://www.ijsr.net/getabstract.php?paperid=ART20201373

Similar Articles

Downloads: 1

Student Project, Pharmaceutical Science, India, Volume 10 Issue 11, November 2021

Pages: 654 - 659

Applicability of Raw Banana as Super Disintegrant in the Design of Bupropion HCl Orodispersible Tablets

Chandini Vegesna, J. Anu Pravallika

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Pharmaceutical Science, India, Volume 12 Issue 8, August 2023

Pages: 2066 - 2071

Formulation and Evaluation of Dolasetron Orally Disintegrating Tablets

S. Jecintha Jebamalar, Dr. L. Karpagavalli

Share this Article

Downloads: 2

Research Paper, Pharmaceutical Science, Libya, Volume 11 Issue 1, January 2022

Pages: 563 - 566

Comparative in-vitro Evaluation of Carbamazepine 200mg Tablets

Tamader Y. Elghnimi, Rehab Balumi, Ahlam Omran, Rema Altife

Share this Article

Downloads: 3

Research Paper, Pharmaceutical Science, Libya, Volume 10 Issue 12, December 2021

Pages: 97 - 104

Pharmaceutical Evaluation of Some Commercial Brands of Metronidazole 500mg Tablets Marketed in Tripoli Libya

Tamader Y. Elghnimi, Amal A. Ammar, Sakina S. Saadawi, Ashaima M. Algeryani

Share this Article

Downloads: 3

Research Paper, Pharmaceutical Science, India, Volume 10 Issue 11, November 2021

Pages: 339 - 345

Applicability of Gum Karaya in the Design of Olmesartan Medoxomil Gastroretentive Floating Tablets

Akondy Keerthana, J. Anu Pravallika

Share this Article
Top