Structural, Antimicrobial and Pharmacological Studies of Fe (II)-5-Fluorouracil Complex

Shuchita Agrawal

Abstract: The coordinating character of 5-Fluorouracil (5-FU) with N and O sites towards metal ion Fe (II) have been synthesized and characterized by elemental, spectral (UV and IR spectroscopy) data as well as by magnetic moment values and conductivity measurements. The amperometric & elemental analysis suggests that the stoichiometry of the Metal: 5-FU 1: 1. The low molar conductance values reveal the non-electrolytic nature of the complex. Magnetic moment values in concert with the electronic spectra indicate that 5-FU coordinates with the metal ion in a bidentate manner through the C = O and N atoms. The antimicrobial activity of the synthesized complex was screened against bacteria viz. Bacillus subtilis, Staphylococcus saphyphiticus, Staphylococcus aureus & Escherichia coli. In-Vitro Cytotoxicity of 5-Fluorouracil -Fe complex is screened against Sarcoma-180 tumor Cells. Fe (II): 5-FU ligand complex shows an increased activity in comparison to the control.

Keywords: Metal liand complex, 5-Fluorouracil, Spectral studies and Antimicrobial activity