Random Use of Recombinant Activated Factor VII in Pediatric Age Groups

Aisha. M. Al-Doroobi, Hayat. H. Obayid, Khalid. B-Kago

Abstract: Bleeding disorders in pediatrics is an important issue and can be life threatening if not diagnosed and treated appropriately. Infants and their families who are affected by these illnesses have poor life quality and often dysfunctional. In this study, we focused on bleeding disorders that have high prevalence in infants and children and are often over looked in other trials and studies where most of their focus was dedicated towards using factor VII in pre-andpost-operative hemorrhages and trauma. We involved 35 patients with various bleedings disorders whom were treated with recombinant factor VII with follow-up over the course of six months. The drug proved its effectiveness with success rate as high as 91.4 % and mortality rate of 8.5 %.

Keywords: Recombinant, Factor VII, Bleeding disorders, Hemorrhage, pediatrics, Hematemesis