Downloads: 246
Research Paper | Biomedical Sciences | Volume 8 Issue 1, January 2019 | Pages: 99 - 103 | India
Study of Serum Endothelin - 1 Variation in Sickle Cell Disease
Abstract: BACKGROUND: Hb level decreased and Serum Endothelin-1 (ET-) level have been observed increased in sickle cell disease. The biological mechanism of synthesis and regulation of the Endothelin-1 (ET-) will be clear. The aim of the research study is to provide an overview of the Hb, CBC count, and Sr. Endothelin-1 level changes and its significance in sickle cell disease. METHODS: Hematological values Complete blood count (CBC) was measured on fully Automatic blood cell counter hematology analyzer (Coulter LH 780), and HmX Hematology Analyzer with Autoloader. But in this study, we have concentrated on the variables like, Haemoglobin - (Hb), WBC, RBC, PCV and MCV count. All the values were compared to the reference values. The ET-1 was determined by using enzyme-immunoassay (ELISA kit) method, specifically designed for direct measurement of plasma ET-1. The sensitivity of the assay is 0.5pg/ml, and the cross-sensitivity of the antibodies used is reported to be
Keywords: Sickle Cell Disease, blood Hb, CBC count, Sr Endothelin-1, bio-marker for the diagnosis
How to Cite?: Chandrakant G. Kamble, Dr. Neeraja Mallik, Dr. P.J.Hisalkar, Dr. Jagdish. D. Powar, Dr. Santosh E.Bidwe, Dr. Bhausaheb V. Jagdale, Dr. Shekhar B. Padhyegurjar, "Study of Serum Endothelin - 1 Variation in Sickle Cell Disease", Volume 8 Issue 1, January 2019, International Journal of Science and Research (IJSR), Pages: 99-103, https://www.ijsr.net/getabstract.php?paperid=ART20194026, DOI: https://dx.doi.org/10.21275/ART20194026