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Research Paper | Chemical Sciences | Iraq | Volume 7 Issue 9, September 2018

Synthesis of Some new Formazan Derivatives Derived from the Coumarin and Study There Biological Activity

Ghaith K. Ibrahim | Khalid A. Albadrany ^[2]

Abstract: This study includes preparing a number of compounds from coumarin, which is like a nucleus for preparing many heterocyclic compounds such as Formazan. As in the following steps. preparing of 7-hydroxy-4-methyl coumarin (G1) of the resorcinol reaction with ethyl aceto ascetate with drops of sulfonic acid, preparing of ethyl 2- ( (4-methyl-2-oxo-2H-chromen-7-yl) oxy) acetate (G2) of a compound reaction (G1) with ethyl chloro acetate with potassium carbonate, preparing of 2- ( (4-methyl-2-oxo-2H-chromen-7-yl) oxy) aceto hydrazide (G3) a compound reaction (G2) with aqueous hydrazine, preparing of (E) -N- (sub. benzylidene) -2- (4-methyl-2-oxo-2H-chromen-7-yl) oxy) acetohydrazide (G4-G10) of a compound reaction (G3) with aldehyde substitutes, preparing of (E, Z) -#- (4-sub. phenyl) -1- (sub. phenyl) -5- (2- ( (4-methyl-2-oxo-2H-chromen-7yl) 0xy) acetyl) farmazan (G11-G24) of a compound reaction (G4-G10) (some Schiff base prepared) with sodium nitrite and -3-amino aceto phenol or -4-amino aceto phenol, The effect of some prepared compounds have been studied on the growth of two types bacterial isolates which are known of their resistance to anti-biotic ( Gr-ve) which is Psedudomonos aeruginosa) and ( GR+ve) which are the Staphylococcus aureus. The anti-biotic Amoxilicine and Ampicillin have been used as samples to control some prepared compounds, and some of the compounds showed good inhabitation activity against the used bacteria.

Keywords: coumarin, Formazan, Schiff bases, Amoxilicine, Ampicillin

Edition: Volume 7 Issue 9, September 2018,

Pages: 822 - 827