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Case Studies | Medical Science | India | Volume 7 Issue 9, September 2018

Papillary Carcinoma of Thyroid with Rhabdoid Phenotype Transformation: Case report with Review of the Literature

Pratima Kujur ^[9] | Shashikala Kosam ^[8]

Abstract: A rare case of anaplastically transformed papillary thyroid carcinoma with a rhabdoid phenotype in recurrence. A 45-year-old women had nodular goiter since 20 years. She had a known case of thyroid carcinoma, right thyroid lobectomy done. After 2 years later, total thyrodectomy specimen received. Histopathologic examination showed anaplastic carcinoma with papillary carcinoma with capsular and vascular invasion. The focus of papillary carcinoma was immunopositive for thyroglobin, TTF1, pancytokeratin with the area exhibiting rhabdoid features being immunopositive for vimentin. A rhabdoid phenotype is a pathological hallmark indicating the aggressive nature not only in the neck region, but also in other organs.

Keywords: immunopositive, papillary carcinoma, rhabdoid, recurrence, vimentin

Edition: Volume 7 Issue 9, September 2018,

Pages: 893 - 896