Effect of Vitamin C and Dialium guineense Fruit Pulp Activity on HO-1, Insulin Secretion and Ace in Experimental Diabetes

Etah Nkanu | Victoria Okon | Ujong Gabriel | Esther George

Abstract: The study was targeted at evaluating the modulatory effect of aqueous fruit pulp of Dialium guineense on hemeoxygenase, insulin, angiotensin converting enzyme (ACE) and possible hypoglycemia in streptozotocin-induced diabetic rats. Twenty four male Wistar rats were randomly divided into four groups control, diabetic control (Dm), diabetic + 300 mg/kg body weight Dialium guineese (Dm+ DG) and diabetic + 500 mg/kg Vitamin C (Dm +Vit. C). Animals were made diabetic by injecting a single dose of 55 mg/kg streptozotocin intraperitoneally. Dialium and Vitamin C were administered orally for three weeks. Result showed significant (p

Keywords: Hemeoxygenase, angiotensin converting enzyme, , Dialium guineense, Diabetes, Vitamin C

Edition: Volume 7 Issue 9, September 2018,

Pages: 355 - 361