International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

Downloads: 116 | Views: 170

Research Paper | Mathematics | Nigeria | Volume 7 Issue 7, July 2018

Modeling the Effect of Coincident Drug-Release Rate and Absorption in Intestinal Lumen

Enobong E. Joshua | Ubon A. Abasiekwere

Abstract: Drug release rate and diffusion are paramount in the delivery of drugs to site of need, whether the drug administration is enteral or parenteral. These phenomena affect the drug absorption. It has been established that the rate of absorption also plays an important role in the drug release process. Although many of the mathematical models take into account the perfect sink condition, in a real system this assumption may not be true as there are many physiological parameters which may affect the drug delivery process. This study establishes that the desirable situation for drug effectiveness and efficacy is when the drug release rate is small compared to the diffusion rate.

Keywords: drug, release rate, absorption, modeling, intestinal lumen

Edition: Volume 7 Issue 7, July 2018,

Pages: 1067 - 1069

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