Serum Uric Acid in Prediabetes

Nabeel Hashmi, T. K. Kamble

Abstract: Background The association between hyperuricemia and diabetes has been proved to be strongly associated with the risk of cardiovascular diseases, but it is not clear whether hyperuricemia is related to the early stage of diabetes. Method Uric acid level was measured by Uricase-PAP methodology in patients with pre-diabetes (n=150) /Control groups (n=150). Uric acid levels in the above two groups were compared based on age, sex and other factors which can affect uric acid level. Results The mean serum uric acid level was lower in control group (3.84mg/dl), rose in pre-diabetics (5.31mg/dl), P value comparing control and pre diabetes was 0.0001, i. e significant. Conclusion Hyperuricemia seems to be associated with pre-diabetes. It can be used as a biomarker of deterioration of glucose metabolism.

Keywords: Hyperuricemia, Prediabetes, uric acid