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Research Paper | Medicine Science | Egypt | Volume 7 Issue 6, June 2018 | Popularity: 6.4 / 10

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Evaluating the Effect of Oral Administration of Artemisia herbaalba Extract Compared to Artesunate on the Mortality Rate of Ehrlich Solid Carcinoma Bearing Mice

Hanan R. H. Mohamed, Mahmoud Amer, Ahmad S.A El Faky

Abstract: Increasing the cancer incidence in the last years, increasing the need for developing new cancer therapy with no toxic effects on human health. Therefore, this study was undertaken to evaluate the effect of Artemisia herba alba extract on the mortality rate of mice bearing solid tumor. Oral administration of Artemisia herba alba extract or Artesunate at the dose level 300 mg/kg decreased the % mortality to 0 % and 30 % compared with control values 10 % and 77 % after five and ten days, of their administration respectively. This effect was better than Cisplatin that reduced mortality rate to only 60 % after ten days of its administration. Conclusion Artemisia herba alba exhibited promising antitumor efficacy with less toxic effects compared with cisplatin.

Keywords: Artemisia herba alba, mortality, cancer and mice

Edition: Volume 7 Issue 6, June 2018

Pages: 579 - 581

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