Granulosa Cell Tumor with Androgenicity

Abstract: Background Granulosa cell tumor (GCT) contributes to 1 % of all ovarian tumors. Their most common presentation is abnormal uterine bleeding, especially in menopausal women. Though rare to have androgenic effects, large cystic GCTs can present with rapid onset virilization. One such case is presented. Case A para 2 aged 46 years, presented with rapid onset hirsutism, acne and 18 x 18 cm cystic ovarian mass. She had attained menopause an year ago. After preoperative evaluation, she was subjected to staging laparotomy. Doppler flow studies did not show loss of resistance. Pathology and immunohistochemistry reported as adult granulosa cell tumor stage 1A, intermediate to high grade necessitating adjuvant chemotherapy with paclitaxel and carboplatin. Conclusion Ovarian tumor presenting with androgenic effects are rare. In women having cystic ovarian tumor, presenting with early menopause and androgenic features, Granulosa cell tumor should be considered in the differential diagnosis for an early initiation of treatment.

Keywords: androgenicity

Edition: Volume 7 Issue 2, February 2018,

Pages: 1579 - 1580