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Research Paper | Chemistry | Iraq | Volume 7 Issue 4, April 2018
Development of Batch and CFIA/Merging Zones Procedures for Estimation of Ganciclovir Drug in Pure Material and Pharmaceutical Preparations using Potassium Permanganate as an Oxidizing Agent
Abstract: A new batch and FIA- merging zones spectrophotometric procedure were developed for the assay of ganciclovir (GCV) in a pure drug and in pharmaceutics preparations. These procedures are characterized by speed, sensitive accuracy and simplicity. The procedure was based on the oxidation of ganciclovir using potassium permanganate as an oxidimetric reagent in alkaline medium to composed a green colored complex was measured at max of 612 nm. The optimized FIA system was able to determine of GCV with throughput 58 sample/h, with 1.2 mL. min-1flow rate employing distilled water as a carrier of chemicals. The calibration curves of absorbance against concentration demonstrate that beer & #039, s law is submitted within the concentration scope of 3-90 & 2-250 mg. L-1 of ganciclovir with detection limits 0.18 and 0.013 mg. L-1 of ganciclovir for batch and CFIA procedures, respectively. The suggested method was carried out successfully for estimation of ganciclovir in dosage forms. The recently developed procedure statistical assessed with standard procedure and there were no considerable contrasts between either procedures. The developed procedure can be adopted as an alternate analytical procedure for estimation of ganciclovir in pharmaceutics samples.
Keywords: Ganciclovir, CFIA / Merging Zones, KMnO4, Spectrophotometric determination, Redox reaction
Edition: Volume 7 Issue 4, April 2018,
Pages: 1733 - 1742