Assessment of Iron Status in Sickle Cell Patients and its relationship with the Frequency of Blood Transfusion
Abstract: Background Sickle Cell Disease (SCD) is common in Indian subcontinent. Sickle Cell Disease (SCD) patients can have iron deficiency or transfusional iron overload. It is important to know the pattern of iron parameters in different clinical states of SCD to decide whether these patients require iron supplementation, blood transfusion or chelation therapy. Materials & Methods The study was conducted in the Department of Pathology, Pt. J. N. M. Medical College and DR. B. R. A. M. Hospital, Raipur, C. G. from January 2015 to august 2016 among patients who attended the OPD and admitted in Paediatrics and Medicine Ward. Serum Iron was measured by Ferrozine/Magnesium Carbonate method using fully automated biochemistry I-Lab 650i autoanalyser. Serum Ferritin was measured by ELISA test kit. Results Out of 100 patients, 58 cases were of Sickle Cell Disease (SCD) and 42 cases were of Sickle Cell Trait (SCT), so the ratio of SCD and SCT patients was 1.381. Male Female ratio was 1.041. Maximum number of cases (67 %) belongs to age group between 5-20 years. Out of 100 patients, 40 % had increased serum ferritin, 50 % had normal and 10 % had decreased level while serum iron level was increased in 23 % patients, normal in 38 % patients and decreased in 39 % patients. Serum iron and serum ferritin level was found normal in 52 % patients of Sickle Cell Disease who had transfused
Keywords: Sickle Cell Patients, Serum Iron, Serum Ferritin, Iron Overload, Iron Deficiency
How to Cite?: Vijay Kapse, Jayanti Chandrakar, Pratima Kujur, Sourabh Kumar Goyal, "Assessment of Iron Status in Sickle Cell Patients and its relationship with the Frequency of Blood Transfusion", Volume 6 Issue 2, February 2017, International Journal of Science and Research (IJSR), Pages: 1371-1374, https://www.ijsr.net/getabstract.php?paperid=ART2017999, DOI: https://dx.doi.org/10.21275/ART2017999