Evaluation of Anti-Depressant Activity of Ethanolic Extract of Justicia Gendarussa Burm with Wister Rat

Mythili A, Jothimanivannan C

Abstract: Objective Justicia gendarussa Burm is an herbal plant that has several therapeutic effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated anti depressant effect of ethanolic extract from Justicia gendarussa Burm by using Forced Swimming Test (FST) [1]. Methods Two doses of ethanolic extract of Justicia gendarussa Burm (250 mg/kg and 500 mg/kg) was injected intraperitoneally. Immobility time and swimming time were measured after 30 min of injection and compared with negative control and imipramine as a positive control. Result The ethanolic extract (500mg/kg) was found to be effective and it exhibited activity similar to that of the conventional drug imipramine (p

Keywords: Justicia gendarussa Burm, Immobility time, Forced Swimming Test, Antidepressant-like effect

How to Cite?: Mythili A, Jothimanivannan C, "Evaluation of Anti-Depressant Activity of Ethanolic Extract of Justicia Gendarussa Burm with Wister Rat", Volume 6 Issue 12, December 2017, International Journal of Science and Research (IJSR), Pages: 885-888, https://www.ijsr.net/getabstract.php?paperid=ART20178833, DOI: https://dx.doi.org/10.21275/ART20178833