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Research Paper | Medicine and Dentistry | Volume 6 Issue 10, October 2017 | Pages: 604 - 607 | Indonesia
Down Regulation of Jun Activation Domain-Binding Protein-1 Induces Cell Cycle Arrest and Apoptosis in a Human Parotid Gland Cancer Cell
Abstract: Jun activation domain-binding protein-1 (Jab1) is a multifunctional protein that regulates cell proliferation, apoptosis and oncogenesis by interacting with and subsequently degrading a large number of proteins. Overexpression of Jab1 indicated the aggressiveness and a poor prognosis of some type of cancers. The antisense (AS) effect was confirmed in a cell line of adenocarcinoma parotid gland (HSY) that also exhibited overexpression of the protein. In the present study, the mechanism responsible for AS mediated cell cycles arrest and apoptosis of HSY cells was examined. The cell cycle arrest of Jab1 AS treated HSY cell was significantly increased when compared with that of control (SC) cells (P
Keywords: Jab1 AS, apoptosis, parotid gland cancer, cell cycle arrest, p27Kip1
How to Cite?: Supriatno, "Down Regulation of Jun Activation Domain-Binding Protein-1 Induces Cell Cycle Arrest and Apoptosis in a Human Parotid Gland Cancer Cell", Volume 6 Issue 10, October 2017, International Journal of Science and Research (IJSR), Pages: 604-607, https://www.ijsr.net/getabstract.php?paperid=ART20177240, DOI: https://dx.doi.org/10.21275/ART20177240