Seroprevalence of High-Risk Human Papilloma virus type 18 (Hr-HPV-18) Infections among Women with HIV-1 Infection on Long Term Suppressive Anti-Retroviral Therapy in a Tertiary Hospital in Jos, Nigeria

Joseph A. Anejo-Okopi, Danladi M. Dashuwa, David S. Adeniyi, Otobo I. Ujah

Abstract: We aimed to determine the sero-prevalence of Hr-HPV-18 among cohort of women with HIV-1 infection on follow up at a Tertiary Hospital, Jos, Nigeria. A cross sectional hospital-based study involving 100 women with confirmed HIV-1infection from a HIV treatment cohort. The blood samples of 91 participants were analyzed using ELISA kit. The mean age of the participants was 37.28.7years. Of the 91 tested samples, 13.2 % were positive to anti-HPV antibodies. The prevalence of anti-HPV 18 antibodies was highest (15.6 %) among women aged 31-44 years and women who were married (16.7 %). Majority of the women were self-employed 49.4 %. Antibodies detected were highest among women with non-formal education (33.3 %). There was statistically significant antibody detection among women who had had at least 3 deliveries. Majority of infection was among those with low CD4. A test of association of all other factors showed no significant association except parity, P=0.044. The proportion of Anti-HPV-18 IgG was low compared with most recent studies. There is the need for larger studies with emphasis on cervical cancer screening programs as well as the introduction of a subsidized vaccine in national immunization scheme which are strategies that can curb the increasing burden of cervical cancer in Nigeria.

Keywords: HPV, High-Risk, Seroprevalence, Women, HIV, Cervical Cancer

How to Cite?: Joseph A. Anejo-Okopi, Danladi M. Dashuwa, David S. Adeniyi, Otobo I. Ujah, "Seroprevalence of High-Risk Human Papilloma virus type 18 (Hr-HPV-18) Infections among Women with HIV-1 Infection on Long Term Suppressive Anti-Retroviral Therapy in a Tertiary Hospital in Jos, Nigeria", Volume 6 Issue 10, October 2017, International Journal of Science and Research (IJSR), Pages: 672-676, https://www.ijsr.net/getabstract.php?paperid=ART20176993, DOI: https://dx.doi.org/10.21275/ART20176993