Which is More Effective; Docetaxel, Doxorubicin and Cyclophosphamide Or 5-Fluorouracil, Doxorubicin and Cyclophosphamide in Adjuvant Treatment of Early Stage Node Positive Breast Cancer?
Abstract: Background The aim of this study is to compare the efficacy and the safety of docetaxel, doxorubicin and cyclophosphamide (TAC) with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) as adjuvant treatment for early stage node positive breast cancer patients. Methods Sixty patients with pathologically confirmed early stage node-positive breast cancer were randomly assigned to receive six cycles of eitherdocetaxel (75mg/m), doxorubicin (50mg/m) and cyclophosphamide (500mg/m) every three weeks or 5-fluorouracil (500mg/m), doxorubicin (50mg/m) and cyclophosphamide (500mg/m) every three weeks as adjuvant treatment. The two chemotherapy regimens were compared in term of disease free survival (DFS) and overall survival (OS). Results At a median follow-up of 30 month, the median estimated rate of DFS for patients in the TAC group was 24 month compared to 20 month for patients in the FAC group which was statistically significant (95 % confidence interval [CI], 0.49 to 7.17, P
Keywords: TAC/FAC, adjuvant, node-positive, breast cancer, survival
How to Cite?: Rehab F Mohamed, Abeer F Amin, Mohamed Alaa Elden Hassan Mohamed, Rania A Abdelhamid, "Which is More Effective; Docetaxel, Doxorubicin and Cyclophosphamide Or 5-Fluorouracil, Doxorubicin and Cyclophosphamide in Adjuvant Treatment of Early Stage Node Positive Breast Cancer?", Volume 6 Issue 9, September 2017, International Journal of Science and Research (IJSR), Pages: 59-64, https://www.ijsr.net/getabstract.php?paperid=ART20176407, DOI: https://dx.doi.org/10.21275/ART20176407