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Research Paper | Pathology | Volume 6 Issue 2, February 2017 | Pages: 28 - 38 | Egypt
Significance of Her2/Neu, C-kit and P63 Immunohistochemical Expression in Bladder Urothelial Carcinoma
Abstract: Background Urothelial carcinoma (UC) is a devastating disease with high mortality rate. Patients at same grade/ stage can have different outcomes, which necessitate better prognostic markers for estimating the risk of progression. Aim To assess the impact of Her2 /Neu, C-kit, and P63 on carcinogenesis and behavior of UC. Methods Her2/Neu, C-kit, and P63 were assessed by immunohistochemistry in 60 cases of UC, and correlated with clinicopathological parameters. Results Her2/Neu was expressed in 40 % of cases. It showed positive expression in 33.3 % of low grade and 44.4 % of high grade UC. It was expressed in 14.3 %, 47.8 % of non-invasive and invasive UC respectively, with significant association with grade and stage (p=0.023,
Keywords: Urothelial carcinoma, Immunohistochemistry, Her2 /Neu, C-kit, P63
How to Cite?: Mai M. Abdelwahab, Samah S. Elbasateeny, "Significance of Her2/Neu, C-kit and P63 Immunohistochemical Expression in Bladder Urothelial Carcinoma", Volume 6 Issue 2, February 2017, International Journal of Science and Research (IJSR), Pages: 28-38, https://www.ijsr.net/getabstract.php?paperid=ART2017540, DOI: https://dx.doi.org/10.21275/ART2017540