Angiogenic Biomarkers of Dysfunctional Uterine Bleeding

Ketki K, Shailesh Kumar

Abstract: Disturbed endometrial angiogenesis plays a role in the mechanism of Dysfunctional uterine bleeding (DUB). Under hypoxic conditions, Hypoxia inducible factor 1 alpha (HIF-1) rapidly accumulates and activates angiogenic growth factors, receptors and extracellular proteases such as matrix metalloproteinases (MMPs) like MMP-9. Copper influences the production of number of angiogenic factors including HIF-1.

Keywords: Angiogenesis, Dysfunctional uterine bleeding DUB, Hypoxia inducible factor 1 alpha HIF-1, Matrix metalloproteinase -9 MMP-9, Copper, Vascular endothelial growth factor VEGF

How to Cite?: Ketki K, Shailesh Kumar, "Angiogenic Biomarkers of Dysfunctional Uterine Bleeding", Volume 6 Issue 5, May 2017, International Journal of Science and Research (IJSR), Pages: 2127-2132, https://www.ijsr.net/getabstract.php?paperid=ART20173820, DOI: https://dx.doi.org/10.21275/ART20173820