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Research Paper | Chemistry | India | Volume 6 Issue 3, March 2017

Improved Process for the Preparation of Halo Substituted Mannich Bases of Substituted Benzimidazoles

Satyanarayana Punna | I. E. Chakravarthy | M. Aswartha Umakantha Reddy

Abstract: Mannich bases are the end products of mannich reaction and are known as beta amino ketone carrying compounds. Mannich reaction is a carbon carbon bond forming nucleophilic addition reaction which helps in synthesizing N-methyl derivatives and many other drug molecules. Mannich base derivatives of benzimidazoles possess many pharmacological properties such as anti-oxidant, anti-inflammatory, anticancer, antiviral, anthelmintic and play an important role in medical field. As these drugs are clinically useful in treatment of microbial infections and exhibit other therapeutic activities also, so this encouraged the development of more potent, novel and clinically significant compounds.

Keywords: Benzimidazoles, Antimicrobial activity, Anti-fungal activity, mannich base, secondary amine

Edition: Volume 6 Issue 3, March 2017,

Pages: 1867 - 1874