Squamous Cell Abnormalities and Risk Factors on 10,979 Pap-Smears in a Tertiary Care Hospital in Trivandrum, South India

Kalavathy MC, Aleyamma Mathew, Sujathan K, Saritha VN, Jagathnath Krishna KM, Jayasree K

Abstract: The study aims at assessing squamous abnormalities and risk factors among women visited a tertiary care hospital for gynaecological problems in Trivandrum, south India. Regional Cancer Centre (RCC), Trivandrum, has been conducting a clinic in Women & Children Hospital, Trivandrum, since 2006, where women attended for gynaec problems were referred to routine Pap-smear. Age and reproductive factors were collected. The processing of the smear was done at RCC. Logistic regression analysis was employed to assess the odds ratio (OR) and 95 % confidence interval (CI).10, 979women had undergone Pap-smear during 2010-2015. Among these, atypical squamous cells of unspecified significance were 2.9 %, low grade squamous intra-epithelial lesions, high-grade squamous intra-epithelial lesions (HSIL) /cancers were 1.6 %. For developing HSIL/cancers women with higher education had OR of 0.20 (CI 0.07-0.58) compared to women with no education. Women with age at marriage >30 years had OR of 0.23 (CI 0.08-0.66) for developing HSIL/cancer compared to women with age at marriage

Keywords: Pap-smear, ASCUS, Squamous Intraepithelial Lesions, LSIL, HSIL