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Research Paper | Chemistry | India | Volume 5 Issue 12, December 2016

Synthesis, Characterization and Microbiological Activity of Schiff Base ?1- (2, 4-Dinitrophenyl) -4- (Substitutedphenyl) -6-{[(4-Chloroyphenyl) Methylene] Amino}-3-Methyl-1, 4-Dihydro Pyrano [2, 3-C] Pyrazole-5-Carbonitrile?

Dr. Shaileshkumar Purshottamdas Prajapati

Abstract: A Schiff Base 1- (2, 4-dinitrophenyl) -4- (substitutedphenyl) -6-{ [ (4-chloroyphenyl) methylene]amino} -3-methyl-1, 4-dihydro pyrano [2, 3-c]pyrazole-5-carbonitrile have been synthesized by reaction between 6-amino-4- (substitutedphenyl) -1- (2, 4-dinitrophenyl) -3-methyl-1, 4-dihy dropyrano [2, 3-c]pyrazole-5-carbonitrile and 4-chlorobenzaldehyde in presence of ethanol the intermediate 6-amino-4- (4-chlorophenyl) -1- (2, 4-dinitrophenyl) -3-methyl-1, 4-dihydropyrano [2, 3-c]pyrazole-5-carbonitrile was synthesised by the reaction between 2, 4-di-Nitro Phenyl Hydrazine and substituted aldehyde in the presence of malano nitrile, piperidine and ethanol 2- (2, 4dinitrophenyl) -5-methyl-2, 4-dihydro-pyrazol-3-one which also synthesized from of ethyl acetoacetate and 2, 4-di-Nitro Phenyl Hydrazine. The synthesized compounds were characterized by means of their IR, 1H-NMR spectral data and elemental analysis. All the synthesized products were evaluated for their antimicrobial activities by Cup borer method.

Keywords: pyrazol-3-one, aldehyde, Ethenol,

Edition: Volume 5 Issue 12, December 2016,

Pages: 1150 - 1153