Anticancer Property of Simple Ascidian Phallusia Nigra Savigny, 1816 against MDA-MB-231 Cells

M. Paripooranaselvi, V. K. Meenakshi

Abstract: Background Breast cancer is one of the most prevalent disease affecting women. Methods Female adult Swiss albino mice weighing 20-25 g were used to assess anticancer activity of the ethanol extract of the simple ascidian Phallusia nigra against human breast cancer cell lines (MDA-MB-231) by evaluating cytotoxicity, relative organ weight of vital organs, tumor weight, % inhibition, solid tumor volume, median survival time, % increase of lifespan, packed cell volume, viable and non-viable cell count adopting standard procedures. Results 100 % cytotoxicity was obtained at 0.60 mg/ml concentration. Negligible changes were noted in relative organ weight. There was a dose dependent increase in % inhibition of tumor and decrease in tumor weight. A highly significant reduction in tumor volume was noted. Median survival time, % increase of life span, non viable cells increased significantly and packed cell volume, viable cells decreased. Conclusion In-vivo studies indicate the presence of bioactive compounds in Phallusia nigra with anticancer property against MDA-MB-231.

Keywords: Phallusia nigra, anticancer, MDA-MB-231 cells

How to Cite?: M. Paripooranaselvi, V. K. Meenakshi, "Anticancer Property of Simple Ascidian Phallusia Nigra Savigny, 1816 against MDA-MB-231 Cells", Volume 5 Issue 12, December 2016, International Journal of Science and Research (IJSR), Pages: 1400-1405, https://www.ijsr.net/getabstract.php?paperid=ART20163645, DOI: https://dx.doi.org/10.21275/ART20163645