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Research Paper | Pharmacology Science | India | Volume 5 Issue 12, December 2016 | Popularity: 6.9 / 10
Anticancer Property of Simple Ascidian Phallusia Nigra Savigny, 1816 against MDA-MB-231 Cells
M. Paripooranaselvi, V. K. Meenakshi
Abstract: Background Breast cancer is one of the most prevalent disease affecting women. Methods Female adult Swiss albino mice weighing 20-25 g were used to assess anticancer activity of the ethanol extract of the simple ascidian Phallusia nigra against human breast cancer cell lines (MDA-MB-231) by evaluating cytotoxicity, relative organ weight of vital organs, tumor weight, % inhibition, solid tumor volume, median survival time, % increase of lifespan, packed cell volume, viable and non-viable cell count adopting standard procedures. Results 100 % cytotoxicity was obtained at 0.60 mg/ml concentration. Negligible changes were noted in relative organ weight. There was a dose dependent increase in % inhibition of tumor and decrease in tumor weight. A highly significant reduction in tumor volume was noted. Median survival time, % increase of life span, non viable cells increased significantly and packed cell volume, viable cells decreased. Conclusion In-vivo studies indicate the presence of bioactive compounds in Phallusia nigra with anticancer property against MDA-MB-231.
Keywords: Phallusia nigra, anticancer, MDA-MB-231 cells
Edition: Volume 5 Issue 12, December 2016
Pages: 1400 - 1405
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