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Research Paper | Medical Surgical | Indonesia | Volume 5 Issue 12, December 2016

The Differences in Level of Interleukin 6 in Lower Limb Orthopedic Surgery with General Anesthesia Technique Compared with Regional Anesthesia Combined Spinal Epidural Block Technique

M. Wiryana | K. Sinardja | G.Budiarta | Tjokorda G.A. Senapathi | I.M.G.Widnyana | Dennis Prakas

Abstract: Background Trauma and surgery caused tissues damage and these will trigger local and systemic inflammation as a defense mechanism and adaptation to injury. Assessment the level of interleukin 6 (IL-6) as an acute phase cytokine is expected to be used as a marker of inflammation caused by the surgery. Anesthesia technique also attenuates the inflammatory response. Objective to find a best anesthesia technique to minimize the inflammatory response in patient with lower limb bones fracture undergoing orthopedic surgery in Operating Theater of Sanglah General Hospital, Denpasar, Bali. Methods This is an observational study, the observation conducted from August to October 2016 in Operating Theatre of Sanglah Hospital. The study involved 28 patients who eligible with a total population sampling technique. Divided into 2 groups, 14 patients received general anesthesia (GA) and 14 patients received regional anesthesia combined spinal epidural block (RA) for the surgery. IL-6 is obtained from peripheral blood before anesthesia conducted and 24 hours after the surgery. Results Patients received RA had a lower level of IL-6 compared to patients received GA 24 hours after surgery. Conclusion Regional anesthesia combined spinal epidural block has a better effect of reducing inflammatory response caused by surgery compared to general anesthesia.

Keywords: Cytokine, IL-6, Inflammatory Response, General Anesthesia, Regional Anesthesia

Edition: Volume 5 Issue 12, December 2016,

Pages: 718 - 721