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Research Paper | Biochemistry Science | Volume 5 Issue 10, October 2016 | Pages: 1166 - 1169 | Iraq
Assessment of Tumor Necrosis Factor Alpha, Homocysteine and Pro-Collagen type III Peptide as Markers in Patients with Moderate to Severe Psoriasis
Abstract: Background psoriasis is chronic and recurrent autoimmune inflammatory disease cause morbidity and mortality. TNF is a Pro-inflammatory cytokine and has a key role in the pathogenesis of psoriasis. Homocysteine level in psoriasis and cause hyperhomocystienaemia that paly role in atherosclerosis and. Procollagen type III peptide is fibro genesis marker methotrexate is widely used in treatment of moderate to severe psoriasis and this lead to develop liver fibrosis, hence measurement of procollagen type III peptide may reduce liver biopsy. Objective 1- measured the level of (TNF), Homocystiene and procollagen type III in patient with moderate and sever psoriasis. and compered the result with healthy control.2- the level of (TNF), Homocystiene and PIIIP in patients before methotrexate and after 4week treatment and Subjects, materials and methods This observational case control study involved thirty patients with moderate to severe psoriasis and thirty healthy contral with matched gender and age with patient groups, used ELISA technique for measured of (TNF and, PIIIP). The Homocystiene is measured by used HPLC technique through de-deproteinization the serum and then mixed with POA reagent for analysis. Results Mean serum Homocystiene was significantly higher in patient group than in control group, 106.42 54.68 versus 50.07 24.16 (P
Keywords: Pro-collagen, Homocystein, TNF, Psoriasis
How to Cite?: Dr. Mohammed I. Hamza, Hasan N. AL_musawi, Anwar H. Mathboob, "Assessment of Tumor Necrosis Factor Alpha, Homocysteine and Pro-Collagen type III Peptide as Markers in Patients with Moderate to Severe Psoriasis", Volume 5 Issue 10, October 2016, International Journal of Science and Research (IJSR), Pages: 1166-1169, https://www.ijsr.net/getabstract.php?paperid=ART20162349, DOI: https://dx.doi.org/10.21275/ART20162349