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Research Paper | Chemistry | India | Volume 3 Issue 6, June 2014

Monoamine Oxidase Inhibitory and Anticonvulsant Activities of Some Substituted Isatin Semicarbazones

Ashok Kumar ^[73] | S. B. Singh ^[4] | Ismail M. Awheda ^[3]

Abstract: Substituted isatin-semicarbazones were synthesized by condensation reaction of appropriate N-substituted-5- (un) substituted isatin with corresponding phenyl semicarbazide and studied for monoamine oxidase (MAO) inhibitory and anticonvulsant activities. In vitro MAO-inhibiting activity was determined by radiometric enzyme assay method in rat liver tissue; and anticonvulsant activity was performed using standard maximal electroshock (MES) induced seizures method in mice. . All of these compounds exhibited MAO inhibiting and anticonvulsant activities; however; there appeared no parallel correlation ship between the activities of these compounds. Thus; these results indicate that MAO inhibiting property does not prove the biochemical basis for the anticonvulsant activity of these compounds. Acute toxicity studies indicate that the compounds have a wide margin of safety.

Keywords: Isatin semicarbazones, synthesis, monoamine oxidase activity, anticonvulsant activity, Acute toxicity

Edition: Volume 3 Issue 6, June 2014,

Pages: 424 - 428