Monoamine Oxidase Inhibitory and Anticonvulsant Activities of Some Substituted Isatin Semicarbazones

Ashok Kumar, S. B. Singh, Ismail M. Awheda

Abstract: Substituted isatin-semicarbazones were synthesized by condensation reaction of appropriate N-substituted-5- (un) substituted isatin with corresponding phenyl semicarbazide and studied for monoamine oxidase (MAO) inhibitory and anticonvulsant activities. In vitro MAO-inhibiting activity was determined by radiometric enzyme assay method in rat liver tissue; and anticonvulsant activity was performed using standard maximal electroshock (MES) induced seizures method in mice. . All of these compounds exhibited MAO inhibiting and anticonvulsant activities; however; there appeared no parallel correlation ship between the activities of these compounds. Thus; these results indicate that MAO inhibiting property does not prove the biochemical basis for the anticonvulsant activity of these compounds. Acute toxicity studies indicate that the compounds have a wide margin of safety.

Keywords: Isatin semicarbazones, synthesis, monoamine oxidase activity, anticonvulsant activity, Acute toxicity

How to Cite?: Ashok Kumar, S. B. Singh, Ismail M. Awheda, "Monoamine Oxidase Inhibitory and Anticonvulsant Activities of Some Substituted Isatin Semicarbazones", Volume 3 Issue 6, June 2014, International Journal of Science and Research (IJSR), Pages: 424-428, https://www.ijsr.net/getabstract.php?paperid=214165, DOI: https://dx.doi.org/10.21275/214165