Determination of Oxomemazine Hydrochloride by Deferential Pulls Voltammetry and Adsorptive Square-Wave Voltammetry at Glassy Carbon Electrode in Pure Form and Pharmaceutical Formulations

Abeer M. Elsied H.

Abstract: Accurate voltammetric methods determination of Oxomemazine hydrochloride are presented at glassy carbon electrode by cyclic, differential pulse and square wave voltammetry (CV, DPV and SWV, respectively). Based on the anodic oxidation peak at approximately 0.898 V in 0.04M B-R buffer (pH 8.0) Cyclic voltammetric studies indicated the oxidation of Oxomemazine hydrochloride at the electrode surface through a single one-electron irreversible step and fundamentally controlled by adsorption. The oxidation peak was used to determine Oxomemazine hydrochloride in range 1.25 M - 10M (r2=0.9903) and 0.37M - 4.5M (r2=0.9924) by DPV and SWV respectively. The procedure was successfully applied for the assay of Oxomemazine hydrochloride in syrup (toplexil). The percentage recoveries were in agreement with those obtained by the reference method.

Keywords: Oxomemazine, differential pulse, Square-wave adsorptive Voltammetry, Glassy carbon electrode