Correlation between Epididymal Semen Quality Parameters and Malondialdehyde Levels in Adults SD rats Liver after Exposure to Bisphenol A.

Ansoumane Kourouma | Yaima M. Lpez Tamayo | Yang Kedi

Abstract: It has been shown that reactive oxygen species (ROS) can lead to deleterious effects on a range of sperm parameters. Bisphenol A (BPA) has been shown to cause injury in the liver by forming ROS and increasing levels of lipid peroxidation. The aim of study was to determine the level of lipid peroxidation as indicated by Malondialdehyde (MDA) in the liver tissue of rats treated with BPA. BPA was mixed in corn oil and intra-peritoneal administered every other day for 20 days in dose dependent manner. After 24 h of the last treatment; rats were weighed; sacrificed and liver harvested for analysis. Epididymal semen quality analysis was performed simultaneously using the CASA system (CFT-9200 computer-aided sperm and microorganism test and analysis system). The levels of MDA increased significantly in the treatment group compared to control group (**P 0.01) and had negative correlation with sperm count; motility and morphology (P

Keywords: Bisphenol A BPA, 2, 2-bis 4-hidroxyphenyl propane, semen quality, sperm count, Liver, Oxidative stress, ROS, MDA

Edition: Volume 3 Issue 6, June 2014,

Pages: 167 - 172