Effect of Crude Aloe vera Gel on Serum Enzymes; Proteins and Liver Histology in Alloxan - Induced Diabetic Rats
Abstract: Considering the wide use of Aloe vera gel in the management of Type 1 Diabetes Mellitus (T1DM) ; this study was designed to ascertain the effects of T1DM on serum enzymes and proteins; as well as the impact of treatment with Aloe vera gel on same. Forty male Wistar rats weighing 150 - 180 g were randomly assigned into 4 groups (n = 10) ; namely; control group; test groups 1 (DM untreated) ; 2 (DM treated) and 3 (control treated). Diabetes was induced by intraperitoneal administration of 100 mg/kg alloxan. Freshly prepared Aloe vera gel was administered to test groups 2 and 3 at a dose of 0.4 ml/100g per oral route for 21 days. The animals were sacrificed; and serum enzymes and proteins were measured using standard methods. Liver histology was also prepared using standard methods. Serum aspartate aminotransferase (AST) concentration was significantly higher (P
Keywords: Aloe vera, diabetes mellitus, liver, serum enzymes, serum proteins
How to Cite?: Akpan, U. P., Nna, V. U., Ikpi, D. E., Osim E. E., Antai, A. B., "Effect of Crude Aloe vera Gel on Serum Enzymes; Proteins and Liver Histology in Alloxan - Induced Diabetic Rats", Volume 3 Issue 6, June 2014, International Journal of Science and Research (IJSR), Pages: 114-119, https://www.ijsr.net/getabstract.php?paperid=2014128, DOI: https://dx.doi.org/10.21275/2014128