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Research Paper | Medicine Science | Pakistan | Volume 3 Issue 5, May 2014

Combination of Allopurinol and Sustained Release Diclofenac Sodium for Treatment of Gout

Yasir Mehmood

Abstract: The present investigation concern with the combination of the two drugs for the treatment of gout. One of these drug is pain killer which is sustain their action within the body for 12 hours and the other drug is antigout which will release as conventional dosge. After oral administration the Diclofenac sodium prolong up to 12 hours and increase patient compliance.6 batches of tablet were developed and evaluate. For the sustain release action of Diclofenac sodium Kollicoat SR 30 and Sicovit 30 combination used with other inactive ingredients. In 1st method only Diclofenac sodium pellets which were sustained released prepared. Pellets of the Diclofenac sodium developed with wet granulation method. This method is easy and cost effective; the evaluation of granules and tablets were done at the end; all prepared material mixed together and form tablet. The tablets were evaluated for all test like appearance; friability; dissolution; hardness; assay; weight variation and in-vitro release profile which is for both API. The result obtained were satisfactory and complies with USP specification. The formulation containing combination of Kollicoat SR 30 and Sicovit 30 showed good sustain release profile for 12 hours. Seperate granules were prepared of both API and check the flow property of these granules and then mixed them for compression.

Keywords: Kollicoat SR 30 and Sicovit 30, Diclofenac sodium, Allopurinol and sustain release

Edition: Volume 3 Issue 5, May 2014,

Pages: 46 - 52