The Pharmacological Evaluation of Cold Water Stem-Bark Extract of Erythrophleum suaveolens On Gastrointestinal Muscle of Guinea-Pig (Cavia porcellus) Ileum

Idyu I I, Olaoye T O, Sokomba E N, Idyu V C, Ramyil M S, Ogbole E A, Builders M I, Ogundeko T O

Abstract: The effect of cold water crude extract of stem-bark of Erythrophleum suaveolens on the activity of an isolated guinea-pig Ileum was studied. Reference drugs (Acetylcholine; Histamine; Barium Chloride; Atropine; Promethazine; and Papaverine) were used both in the presence and absence of E. suaveolens extract. Preliminary pharmacological investigation of the extract revealed inhibitory effects. Thus; investigations carried out on the isolated ileum tissue of the guinea-pig (Cavia porcellus) by running a dose-response relationship of the agonist test drugs (Acetylcholine; Histamine; and Barium Chloride) in the presence of the cold water crude extract of stem-bark of Erythrophleum suaveolens ascertained antagonist nature of the extract with a right shift. However; the degree of shift in presence of Barium Chloride is less than that with Histamine and Acetylcholine respectively.

Keywords: Erythrophleum suaveolens, Blocking/Inhibitory effect, Cavia porcellus Ileum, Antagonist