Antifertility Activity of Different Extracts of Mimosa Pudica Linn Leaves in Female Rats

Y. Jamuna Devi

Abstract: Alcolholic, water and petroleum ether extracts of Mimosa pudica Linn leaves was screened for their antifertility activity at the doses of 50, 100, 150mg/KG body weight in female rats. Oral administration of 150mg/kg body weight of all extracts for 1-7 days of post coitum was found to be optimum and most effective dose for antifertility activity. At 50mg/kg body weight implantation sites were observed with water, alcoholic and petroleum ether treated group showing 40, 80 and 40 % antifertility activity. Maximum antifertility was observed after administration of the extract group at a dose of 150mg/kg body wt. From day 1-7 of pregnancy showing 80, 100 % antifertility activity. It is well established that the inhibition of implantation in albino rats is due to imbalance of progesterone, estrogen ratio.

Keywords: Antifertility, Mimosa pudica, Female rats, implantation, Pregnancy