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Research Paper | Oncology Science | India | Volume 3 Issue 1, January 2014

Chronic Myeloid Leukemia - An Overview

Jayita Dey Mondal ^[2] | Dalia Tewary ^[2] | Samadrita Mukherjee Sardar ^[2]

Abstract: CML is a myeloproliferative disorder characterized by a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), a balanced translocation, involving a fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) on chromosome 22q11. The molecular consequence of this translocation is the generation of a BCR-ABL fusion oncogene, which translates into Bcr-Abl oncoprotein with increased tyrosine kinase activity. (1)

Keywords: Chronic Myeloid Leukemia

Edition: Volume 3 Issue 1, January 2014,

Pages: 129 - 132