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Research Paper | Oncology Science | Volume 3 Issue 1, January 2014 | Pages: 129 - 132 | India
Chronic Myeloid Leukemia - An Overview
Abstract: CML is a myeloproliferative disorder characterized by a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), a balanced translocation, involving a fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) on chromosome 22q11. The molecular consequence of this translocation is the generation of a BCR-ABL fusion oncogene, which translates into Bcr-Abl oncoprotein with increased tyrosine kinase activity. (1)
Keywords: Chronic Myeloid Leukemia
How to Cite?: Jayita Dey Mondal, Dalia Tewary, Samadrita Mukherjee Sardar, "Chronic Myeloid Leukemia - An Overview", Volume 3 Issue 1, January 2014, International Journal of Science and Research (IJSR), Pages: 129-132, https://www.ijsr.net/getabstract.php?paperid=02013742, DOI: https://dx.doi.org/10.21275/02013742