Assessment of Toxic Effects of the Endocrine Disruptor Bisphenol-A on Zebra Fish (Danio Rerio) - A Vertebrate System

Bisphenol A (BPA) is considered to be one of the important component of plastics, BPA is regarded to be an endocrine disruptor thereby interfering with the production, secretion, transport, action, function and elimination of natural hormones. In the present study the toxic effects of BPA was assessed on mature adult zebra fishes and young fragile embryos. Zebra fishes were grown in reverse osmosis water containing known concentrations of BPA ranging from 0.01Molar (M) to 0.1M. After spawning the young fragile embryos were also subjected to BPA treatment the result of which was mortality of the adult fishes and young embryos. The toxicity of the same was determined in-vivo by measuring the acetyl cholinesterase (AChE) activity in the brain tissue of zebra fish. The results projected a very high AChE activity indicating neuro transmission obstruction and mortality of the zebra fishes.