Waleed A. Mahmoud, Fadhil M. Abid, Zahraa A. Mahdi
Abstract: The selenocystine complex was biologically prepared by using local yeast; the prepared complex was characterized by using appropriate physical measurement i.e. FAAS, FTIR spectroscopy and melting point and analyzed by reversed phase HPLC and was compared with authentic standard. To treatment the deficiency level of selenium in hypertension and myocardial infarction patients, the complex was formulated at estate of drug and medical appliance in Sammara (in Iraq) as tablets. The present study involved the following groups: 1-100 healthy volunteers (55 men, 45women), 2-50 patients with myocardial infarction (men) and 3-50 patients with hypertension (men). The concentration of selenium was determined in the blood serum of healthy and patients volunteers by using graphite furnace atomic absorption. The results showed that patients with hypertension and myocardial infarction had lower concentration of selenium in blood serum as compared with the healthy group. We supplied (20) patients with myocardial infarction and (20) patients with hypertension with (200mg) selenocystine complex tablet for three months. The results showed the selenium concentration in blood serum of hypertension patients were elevated from (42-53ng/ml) to (71-63ng/ml) and for myocardial infarction patients, the concentration were elevated from (35-45ng/ml) to (72-66ng/ml).
Keywords: Synthesis, Complex, Medicine, Yeast