Dr. Keyur J. Paneliya, Dr. Jigna D. Dave
Abstract: Background: Shorter MDR-TB (Multi Drug Resistant) Regimen is widely used for Pulmonary MDR Tuberculosis patients and there is much less data regarding the outcome of this regimen. Material and Method: The study is record based. The study enrolled 50 MDR PTB patients started on shorter MDR-TB regimen at department of Respiratory Medicine, Sir T Hospital, Bhavnagar from April 2018 to December 2018.Data regarding follow up sputum smear, sputum culture and outcome of patients started on shorter MDR regimen was collected from DTC Bhavnagar. Observation: Out of 50 patients enrolled in the study, 52 % (26/50) patients completed the regimen, 26 % (13/50) patients defaulted the treatment and 22 % (11/50) died during the study. 23 % (6/26) had positive end IP culture and 77 % (20/26) had negative end IP culture. 23 % (6/26) had positive end CP culture, 58 % (15/26) had negative end CP culture and end CP culture were not sent in 19 % due to change of regimen. 19 % (5/26) reported FQ resistance, 4 % (1/26) reported SLID resistance. 30 % (15/50) patients were cured, 12 % (6/50) had treatment failure, 10 % (5/50) were put on newer regimen. Conclusion: Even though Shorter MDR regimen is cost effective and of short (9-11 months) duration, outcome of Shorter MDR regimen depends on patients compliance and pattern of resistance to second line drugs.
Keywords: Multi Drug Resistant Tuberculosis, Shorter Regimen, End IP Culture, End CP Culture