Jenie Palupi, Syiska Atik Maryanti
Abstract: Kecombrang or Etligera Elatior has been carried out the study contains the presence of flavonoids, tannins, saponins, quinones, steroids. Kecombrang is able to reduce the fertility of white mice (Mus musculus) breastfeeding because it contains prolactin hormone that suppress GnRH. This research is a laboratory experimental research type of post test design with experiment and control group (Post test only control group design). This research was conducted to study the effect of kecombrang (Etlingera elatior) to change the weight of infant mice (Mus musculus). In this study, measurements of prolactin levels were observed with weight changes in mice after 12 days of administered aqueous solutions at various doses and observed on the 3rd, 6th, 9th and 12th days. Oneway Anova weight change of mice by treatment of aqueous solution at various doses showed that administration of kecombrang solution at various doses had no significant effect on weight change at 3 day observation with F-count value of 1.012 and significance of 0.399. This also happened to the next observations, i.e, observation day 6 with F-count of 2, 183 (p = 0, 107), observation day 9 with F-count equal to 1, 087 (p = 0, 367) and observation day 12 with an F-count of 0.440 (p = 0.726). Oneway Anova results there is no significant effect between the treatment of giving a solution of kecombrang at various doses of weight changes. Estrogen significantly stimulates the synthesis and release of prolactin by pituitary, this effect depends on the duration and dose of administration.
Keywords: prolactin, kecombrang, body weight, mice