Downloads: 126
Research Paper | Chemistry | India | Volume 4 Issue 1, January 2015
Synthesis, Characterization and Evaluation of Antimicrobial Activity of Various Mannich Bases of Isoindoledione Derivatives
Chakrawarti Prasun | S. R. Wakode [2]
Abstract: Isoindoledione possess a structural featureCO-N (R) -CO-, an imide ring which help them to be biologically active and pharmaceutically useful. Isoindoledione have received attention due to their antibacterial, antifungal, analgesic, antitumor, anxiolytic and anti HIV-1 activities. When Isoindoledione is subjected to Mannich condensation, it yields Mannich bases which may display more biological activities. The increasing popularity of the Mannich reaction has been fueled by the ubiquitous nature of nitrogen containing compounds in drugs and natural products. The aim of the present study is to synthesis Mannich bases of Isoindoledione by Mannich condensation reaction. Isoindoledione reacts with various substituted aromatic aldehydes and substituted amines in presence of mineral acid to give various Mannich bases of Isoindoledione. The synthesized compounds will be characterized by elemental analysis, TLC and structure will confirmed by IR analysis and NMR analysis. Antimicrobial screening of the compounds will be carried out using Serial dilution method.
Keywords: Isoindoledione, Phthalimide, Mannich base, N-Mannich base, antimicrobial activity, parallel synthesizer, MIC
Edition: Volume 4 Issue 1, January 2015,
Pages: 2624 - 2628
Similar Articles with Keyword 'Phthalimide'
Downloads: 112
Research Paper, Chemistry, Iraq, Volume 6 Issue 8, August 2017
Pages: 1498 - 1504Synthesis and Modification of New Phenolic Resins Bearing Pendant 1,8-Naphthalimides
Ahlam Marouf Al-Azzawi [4] | Esraa Faiq
Downloads: 123
Research Paper, Chemistry, Iraq, Volume 6 Issue 11, November 2017
Pages: 1000 - 1008Synthesis and Copolymerization of Several New N-(allyloxy phenyl) tetrachlorophthalimides
Ahlam Marouf Al-Azzawi [4] | Hiba Kadhim Yaseen [2]