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Review Papers | Medicine Science | Bulgaria | Volume 4 Issue 5, May 2015
Oxidative Stress in Parkinsons Disease
Mancheva-Ganeva Velina [6] | Manchev Lachezar [6] | Ganev Iordan [5] | Manchev Ivan [6]
Abstract: Dopamine required for neuronal signaling is vesicle bound and redox inert. When it is released from the vesicles into the cytoplasm it is able to influence iron metabolism and undergo redox reactions that result in the formation of neuromelanin and ROS. Neuromelanin in turn will also influence iron metabolism and lead to the production of ROS. The equilibrium between vesicle bound dopamine and cytoplasmic dopamine is regulated by alpha-synuclein. Mutations in this protein shift the dopamine equilibrium in favour of the cytoplasm. In the presence of iron and under conditions of oxidative stress alpha-synuclem will aggregate and form deposits.
Keywords: Oxidative stress, Parkinson's disease
Edition: Volume 4 Issue 5, May 2015,
Pages: 3061 - 3064
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Research Paper, Medicine Science, Iraq, Volume 4 Issue 11, November 2015
Pages: 2262 - 2264Evaluate the Effect of Coenzymeq10 Supplementation on Reducing Oxidative Stress in Patients with Relapsing Remitting Multiple Sclerosis
Mariam Omran Waheed | Haider Al- Tukmagi | Ali Kadhim Kareem
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Review Papers, Medicine Science, Bulgaria, Volume 4 Issue 5, May 2015
Pages: 2433 - 2435Neurodegenerative Diseases and Oxidative Stress
Mancheva-Ganeva Velina [6] | Gadjeva V | Manchev Lachezar [6] | Ganev Iordan [5] | Manchev Ivan [6]