Downloads: 116 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper | Medicine Science | Egypt | Volume 4 Issue 2, February 2015
Potential Toxicity of Egyptian Ashwagandha: Significance for their Therapeutic Bioactivity and Anticancer Properties
Wafaa Abdallah Ahmed | Mohamed A. [19] | Nasser E. A. | Doaa E.
Abstract: Chemotherapy is usually given early after diagnosis in several cancer subtypes to offer best results. However, chemotherapeutic drugs are often associated with some degree of toxicities, which are caused by reactive metabolites generated by the biotransformation of anticancer drugs in the liver. Phytochemicals are dietary phytoestrogens that may play a role in cancer prevention and treatment. Forty percent of Americans use complementary and alternative medicines (CAM) for disease prevention and therapy. Ashwagandha (Withania somnifera) contains flavonoids and active ingredients like alkaloids and steroidal lactones which are called Withanolides. We hypothesize that the immune-modulatory and anti-inflammatory properties of Ashwagandha might contribute to its overall effectiveness as an anti-carcinogenic agent. Ashwagandha is one of the most versatile plants used in the traditional Indian medicine system (Ayurvedic). The goal of this study is evaluate the therapeutic bioactivity and cytotoxic effect of Egyptian Ashwagandha on hepatocellular carcinoma cell line (HepG2). The HepG2 cells treated by different doses of Ashwagandha root extract. The viability and cytotoxicity were measured by trypan blue and MTT assay. In conclusion Ashwagandh can inhibit cell proliferation and induce cytotoxic effect on hepatocellular cancer cells.
Keywords: Egyptian Ashwagandha, Hepatocellular Carcinoma Cell Line Antitumor activity
Edition: Volume 4 Issue 2, February 2015,
Pages: 2170 - 2176
Similar Articles with Keyword 'Egyptian'
Downloads: 112
Research Paper, Medicine Science, Kuwait, Volume 4 Issue 11, November 2015
Pages: 1044 - 1052Evaluation of Small Bowel Bacterial Overgrowth Syndrome (SBBOS) in Egyptian Patients with Unexplained Gastrointestinal Symptoms: Histopathologic Features and Clinical Correlates in an Under Recognized Entity
Yasser S. Sheta [4] | Abdallah Nawara | Elsayed A. Elgohary [5] | Abeer M. Hafez [5] | Samar S. Morsi
Downloads: 112
Research Paper, Medicine Science, Egypt, Volume 6 Issue 5, May 2017
Pages: 1187 - 1192Amino Acid Substitution in Hepatitis C Virus Core and Genetic Variation in Interleukin 28? Gene and their Correlation to Interferon Treatment Failure in Chronic HCV Egyptian Patients
Nashwa El-Khazragy [2] | Maiada A. Hussien | Mohamed A. El-Mordy | Amany M. Maher