Downloading: A Concise and Convenient Synthesis of 6-Aryl Angular Phenothiazinones
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064


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A Concise and Convenient Synthesis of 6-Aryl Angular Phenothiazinones

Ijeomah A.O, Okoro U.C., Godwin-Nwakwasi E.U

Abstract: The synthesis of 6-aryl derivatives of 8-methyl-11-azabenzo[a]phenothiazn-5-one is reported. This was achieved by reacting 2-amino-4-methylpyridine-3-thiol with 2, 3-dichloro-1-4-naphthoquinone under anhydrous basic condition to furnish the parent compound while 6-aryl derivatives were prepared by cross-coupling with arylboronic acids under nickel complex catalysis. The structures assigned to the synthesized compound were supported by spectroscopic and analytical data obtained.

Keywords: Synthesis, 2-amino-4-methylpyridine-3-thiol, 2, 3-dichloronapthoquinone, 8-methyl-11-azabenzoaphenothiazine-5-one


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