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Masters Thesis | Biomedical Sciences | Indonesia | Volume 10 Issue 4, April 2021
Comparison between Oral Administration of Kaempferia galanga Rhizome Extract and Simvastatin in Improving Lipid Profile of Dyslipidemic Male Wistar Rats
Sonia Hermawan | IGM Aman | Ni Nyoman Ayu Dewi [3]
Abstract: Introduction: Dyslipidemia has the potential to cause atherosclerosis which leads to cardiovascular disease. Kaempferia galanga rhizome is known to contain various components as antioxidants those affect on lipid profile improvement. This study aimed to determine the effect of Kaempferia galanga rhizome extract on improving the lipid profile of male Wistar rats with dyslipidemia. Methods: An experimental study with a randomized pretest-posttest control group design was conducted on 14 male Wistar rats, aged 2-2.5 months which suffered from dyslipidemia. Subjects were divided into two balanced groups, namely the control group (administrated with simvastatin 0.36mg) and the study group (administrated with Kaempferia galanga rhizome extract 100 mg) for 14 days. Lipid profiles were measured before and after treatment. The data were analyzed using a compare mean test. Results: The results showed no significant difference in total cholesterol levels between the two groups pretest (p = 0.336) and posttest (p = 0.038), triglycerides between the two groups pretest (p = 0.447) and posttest (p =0.923), LDL between the two groups pretest (p = 0.515) and posttest (p = 0.052), and HDL between the two groups pretest (p = 0.354) and after posttest (p = 0.574). Although there was significant difference in p-total cholesterol values in the two groups pretest and posttest, the pre-post mean difference between the two groups showed no significant difference from the difference between pre-post total cholesterol (p = 0.117). Conclusion: The results of this study indicated that there was a significant improvement in the lipid profile with both Kaempferia galanga rhizome extract and simvastatin. The improvement in lipid profile was not significantly different from the administration of Kaempferia galanga rhizome extract or simvastatin.
Keywords: Cholesterol, Dyslipidemia, Kaempferia galanga Rhizome Extract
Edition: Volume 10 Issue 4, April 2021,
Pages: 545 - 549
Similar Articles with Keyword 'Cholesterol'
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Masters Thesis, Biomedical Sciences, Indonesia, Volume 10 Issue 6, June 2021
Pages: 336 - 339Comparison between Oral Simvastatin and the Addition of Mung Bean Sprout (Vigna radiata) Extract to Improve Lipid Profile and Decrease F2-isoprostane Level in Wistar Male Rats (Rattus norvegicus) with Dyslipidemia
Jessica Novia Chandra Wijaya | Anak Agung Gde Budhiarta [3] | Ida Sri Iswari [5]
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Research Paper, Biomedical Sciences, Indonesia, Volume 12 Issue 12, December 2023
Pages: 2003 - 2013Biochemical Profile of White Rat Blood during Mating and Pregnancy Treated with Steeping Water of Dried Gedi Leaves (Abelmoschus manihot)
Dingse Pandiangan [13] | Michael Vallery Loueis Tumbol | Nelson Nainggolan [6] | Elvina Artha Nainggolan [3] | Ivana Cristy Nainggolan | Verina Putri Nainggolan