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Masters Thesis | Biomedical Sciences | Indonesia | Volume 10 Issue 1, January 2021
Administration of Butterfly Pea (Clitoria ternatea) Flower Etanol Extract Oral Increased the Number of Pancreatic Beta Cells and Decrease the Level of Glycated Hemoglobin (HbA1C) of Diabetic Male Wistar Rats (Rattus norvegicus)
Viena Valentine | Anak Agung Gede Budhiarta | Anak Agung Ayu Ngurah Susraini [6]
Abstract: Type 2 Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia that occurs due to abnormalities in insulin secretion, insulin action or both. Chronic hyperglycemia causes a cumulation of glucose and hemoglobin bonds and an increase in the level of HbA1c. Experimental research was conducted with a randomized posttest only control group design. Subjects were while male Wistar rats (Rattus norvegicus).36 animals treatment group were divided into two group (n=18 individuals). The control group was given aquabidest and glimepiride (0, 036mg/200gr body weight), and the treatment group was given butterfly pea flower part extract (80mg/200gr body weight) and glimepiride (0, 036mg/200gr body weight) via sonde once per day for 60 days. After 60 days of treatment, the immunohistochemical examination of pancreatic beta cells and HbA1c levels with the Rat Hemoglobin HbA1c Elisa kit. Analysis of pancreatic beta cells is the average number of pancreatic beta cells from all Langerhans islands in a three field preparation of 400x magnification by means of zigzag, the number of pancreatic beta cells is summed then averaged to get the mean number of pancreatic beta cells per large field of view. Result: There was a significant difference in the number of pancreatic beta cells in the treatment group 19.54±8.11 cells/field of view compared to the control group 8.84±5.32 cells/field of view (p<0.001). Meanwhile, in the HbA1c level there was a significant difference in in the HbA1c level in the treatment group 28.91±8.73 ng/mL when compared to the control group 35.78 ± 8.96 ng/mL (p 0.013). Based on the results of this study it can be concluded that the combination of butterfly pea flower part extract and glimepiride increased the number of pancreatic beta cells and decreased the levels of HbA1c in diabetic male Wistar rats.
Keywords: Butterfly pea, DM, HbA1c, Pancreatic beta cells
Edition: Volume 10 Issue 1, January 2021,
Pages: 1369 - 1373
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Research Paper, Biomedical Sciences, Indonesia, Volume 10 Issue 8, August 2021
Pages: 852 - 856Administration of Myrmecodia pendans Ethanol Extract Cream Prevented Elevation of Keratinocyte Apoptosis and Number of Macrophages in Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B (UVB)
Diana Utami | Wimpie Pangkahila [22] | I Gusti Made Aman [5]
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Masters Thesis, Biomedical Sciences, Indonesia, Volume 11 Issue 5, May 2022
Pages: 795 - 799The Administration of 35% Chocolate Seaweed (Sargassum polycystum) Extract Cream Does Not Inhibit TGF-?1 Decrease But Inhibit Collagen Decrease in Wistar Rats Exposed to Ultraviolet B
Finta Lidanang | Agus Eka Darwinata | Ni Putu Sriwidyani [8]