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Research Paper | Biomedical Sciences | Indonesia | Volume 9 Issue 6, June 2020

Effectiveness of Compounded Bioidentical Hormone Replacement Therapy (BHRT) Cream for Menopausal Women: A Clinical Study

Trifena ^[2] | Pangkahila.W | Budhiarta A.A.G

Abstract: Hormone replacement therapy with bio-identical hormones (BHRT) has been widely employed to improve menopause syndromes though not yet widely supported with landmark trial as to their efficacy in improving menopause syndromes. Based on this hypothesis, this trial explores the efficacy of compounded BHRT in increasing the serum level as well as the menopause syndromes. The objective of this study is to evaluate the effectiveness of compounded BHRT cream which contain Progesterone 10 % and Bi estrogen 0.25 % for menopausal women. The experimental trial conducted with Pretest-Post test Control Group on 28 menopausal women aged 45-65 years, divided in two groups given with test (containing Progesterone 10 % and Bi estrogen 0.25 %) and placebo cream (cream base without actives). Patient symptom severity was compared at baseline and to 2 months follow-up using the Greene climacteric scale and complete a new patient evaluation form and a laboratory hormone panel (progesterone and estradiol) prior to their initial visit. Results show that the serum levels as well as the Greene climacteric scale between the test and placebo group before the trial did not show difference (independent t test) However, the post test did show difference between the two groups in terms of serum levels as well as the Greene climacteric scale. (p<0.05) The study has proven that trans dermal application of compounded progesterone and bi estrogen cream can increase the serum levels of progesterone and estradiol while at the same time improves the menopause syndromes. Based on this study, further studies can be organized to further conclude the efficacy of BHRT.

Keywords: menopause, progesterone, estrogen, hormone replacement therapy, bio-identical, trans dermal, BHRT

Edition: Volume 9 Issue 6, June 2020,

Pages: 1518 - 1520

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