Joao Oliverio Ribeiro, Joao Pinto Machado, Sara Macedo, Eurico Oliveira
Abstract: Paget's bone disease is a chronic pathology that affects the osseous turnover, with favourable prognosis if treated early. Most patients are asymptomatic, but pain is a frequent clinical manifestation. The authors present a case of a patient, with a mechanic lumbosciatalgia, with 4 months of evolution, progressive worsening on the previous days, at the time with inflammatory component. He had a lumbar-sacred CT-scan revealing ?grossly trabecular areas alternating with lytic areas on D11, L2, L5 and sacrum, evoking vertebral angiomas but not excluding infiltrative lesion? and blood samples with increased Sedimentation Rate (SR), Alkaline Phosphatase (AP) and ?-2-Microgobulin, and an electrophoretic proteinogram with ?-2-Mycroglobulin peak. He was hospitalized and performed a bone scintigraphy that revealed multiple increased uptake lesions, and analysis that showed an increase in Bone AP and Collagen Telopeptides. Correlating clinical findings, imaging, analysis and excluding other diseases the diagnosis of Paget?s Bone Disease was established.
Keywords: Paget Disease of bone, Quality of Life, Pain, Byposphonates