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Case Studies | Medicine | India | Volume 9 Issue 4, April 2020

Analysis of Adverse Drug Reactions and Treatment Outcome of DOTS Plus Therapy of MDR-TB Patients at District Tuberculosis Centre

Dr. Meghavi S. Bhapal | Dr. Dharitri D. Thakar | Dr. Harshit G.N | Dr. Ketan Kumar Patel

Abstract: Background: Expensive and toxic second lines anti tubercular drugs are given under the programme for a longer period of time for the treatment of MDR-TB. However despite being implemented in whole of country, data on programme surveillance is scarce. Adverse drug reactions of second line anti-tubercular drugs affect compliance and thereby treatment outcome. Hence the present study was sought to evaluate the treatment outcome and analyze adverse drug reactions of MDR-TB receiving DOTS plus therapy under programme. Methods: Retrospective study of registered MDR TB cases at district tuberculosis center data regarding demoghaphic profile, ADRs, drug adherence, outcome recorded and analysed. Results: Majority of ADR were Gastrointestinal (46.36 %) followed by generalized weakness (20 %), joint pain (11.81 %), psychological (6.36 %) and others. patients had favorable outcome, amongst them 44 patient were cured and 5 completed treatment.32 patients had unfavorable outcome, amongst them 19 patients died, 9 became defaulter, 3 became failure to therapy, 1 shifted to bedaquiline based regimen. Conclusions: Cure rate was higher in MDR-TB cases with ADRS than MDR-TB cases without ADR and poor treatment adherence have unfavourable outcome. Objectives: 1) To Study Adverse drug reactions in MDR TB cases.2) To evaluate and analyze outcome in MDR TB patients.

Keywords: AKT-anti koch treatment, MDR-TB -multidrug resistant tuberculosis, DOTS- directly observed treatment, short course, PMDT- programmatic management of drug resistant TB

Edition: Volume 9 Issue 4, April 2020,

Pages: 1775 - 1777

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