Dr. M. Venkat Rama Rao, Dr. T. Surya Sree
Abstract: AIM: To compare the efficacy of Esmolol Hcl& Lignocaine Hcl in attenuation of hemodynamic response to Laryngoscopy and Endotracheal Intubation. MATERIALS & METHODOLOGY: A randomized, prospective, double-blind study in which 60 patients of ASA grade I or II aged between 20–60 years was conducted. LignocaineHcl 1 mg/kg and Esmolol Hcl 0.5 mg/kg were compared in attenuating the haemodynamic response to laryngoscopy and tracheal intubation in elective surgery under general anaesthesia. Patients were divided into two groups Group L (Lignocaine): patients receive injection Lignocaine, 1 mg/kg IV bolus diluted to 10 ml with 0.9 % saline.Group E (Esmolol): patients receives injection Esmolol 0.5 mg/kg IV bolus diluted to 10 ml with 0.9 % saline. All the selected patients are subjected to the same anaesthesia technique. HR, SBP, DBP and MAP were recorded before intubation, and then during intubation 0 minute, 1 min, 3 min, 5 min of intubation. RESULTS: Systolic, Diastolic & Mean Arterial Pressures increased significantly in lignocaine group whereas it was attenuated more effectively in Esmolol group (p<0.05). CONCLUSION: Esmolol is more effective than lignocaine in attenuating the haemodynamic response to laryngoscopy and tracheal intubation.
Keywords: Esmolol, Lignocaine, haemodynamic response, General anaesthesia