The miRNA-106b-5p Target in Caspase 6 Induces Neuronal Cell Death in Epileptogenesis

Harkitasari S | Maliawan S

Abstract: Epilepsy is a chronic neurological disease that is often found and associated with specific neuropathology. Epilepsy is a heterogeneous condition characterized by hyperexcitability of neurons and recurring, spontaneous seizures. This disease is a common brain disorder and affects about 1 % of the population. Epilepsy is the second highest number of health problems affecting 50-70 million people worldwide. As many as 2.4 million people have been diagnosed with epilepsy every year. In developing countries there are as many as 80 % of epilepsy cases and three-quarters of them do not get proper therapy. The diagnosis of epilepsy can be seen from clinical manifestations and is supported by the neurophysiological features typical of electroencephalogram for epilepsy, namely the presence of epileptic waves. Physicians often have difficulty in establishing the diagnosis of this disease, moreover clinical manifestations are similar to seizures and EEG images do not always show waves that are typical of an epileptic wave. There are no biomarkers, especially non-invasive ones to help make the diagnosis of this disease. The development of diagnostic biomarkers in epilepsy has added insight into epileptogenesis, so that therapeutic targets and adequate therapies can be developed in the future. This biomarker also prevents misdiagnosis and increases the prevention of epilepsy. To achieve the success of this vision, evidence of the underlying mechanism of action of epileptogenesis is needed. Experimental studies and clinical imaging of epileptics show that seizures result in neuronal death. Neuronal cell death as a basis for epileptogenesis is still controversial. The apoptotic pathway may play a role in the pathogenesis of epilepsy.6 The intrinsic apoptosis pathway is a relevant pathway in neuronal death induced by seizures. Induction of cell death in this pathway originates from disorders in the cell, the damage to deoxyribonucleic acid (DNA), endoplasmic reticulum stress

Keywords: miR-106b-5p, caspase 6, Epileptogenesis

Edition: Volume 9 Issue 4, April 2020,

Pages: 379 - 386